Preimplantation Genetic Testing for Aneuploidy (PGT-A) and Mendelian (PGT-M)

If you have been struggling with infertility and miscarriages, and are considering In Vitro Fertilization (IVF), you should know that there may be an underlying genetic cause.

According to the World Health Organization, for every 300,000 live born babies, one will die within the first four weeks due to a chromosomal abnormality. These are commonly structural and functional anomalies which take place during development and are only detected or after birth.

To prevent this, science in Reproductive Health, has developed Preimplantation Genetic Testing tools, such as Preimplantation Genetic Testing for Aneuploidy (PGT-A ) and Preimplantation Genetic Testing for Mendelian disorders (PGT-M).

PGT-A and PGT-M are both performed on cells obtained from an embryo biopsy at our embryology lab, but they have different purposes and screen for different genetic problems.

Both are important treatment options available for patients undergoing IVF treatments. Both techniques have been standardized at Ingenes and are additional to our fertility treatments, allowing us to thoroughly evaluate the 23 pairs of chromosomes, previous to embryonic transfer to the uterus of the future mother.

Preimplantation Genetic Testing (PGT-A)

PGT-A profiles potential abnormal chromosomal numbers – gains, known as trisomy, or losses, known as monosomy – which are commonly associated to implantation failures, miscarriages, and certain syndromes that are compatible with life.

PGT-A is recommended for patients who are starting IVF, who have no known specific genetic abnormality, as well as for:

  • Women that are 35 years or older
  • Men that are 38 years or older
  • Couples interested in a single embryo transfer
  • Women with a history of pregnancy loss or recurrent miscarriages
  • Couples with a history of implantation failures

PGT-A really can be a game-changer because it permits the reproductive Medical Doctor to transfer only the embryos with a normal chromosomal number, increasing the chances of a successful IVF.

Among the most common genetic diseases and syndromes detected by PGT-A at Ingenes are: Down Syndrome, Edwards, Patau and Klinefelter.  PGT-A also screens for gender. This allows your reproductive Medical Doctor to select embryos of a specific gender to avoid sex-linked genetic disorders such as Turner Syndrome.

Preimplantation Genetic Testing for Mendelian disorders (PGT-M)

PGT-M  detects a specific mutation, deletion or insertion,  present on a single gene, resulting on a monogenic disorder or a chromosomal segmental rearrangement such as an inversion or translocation both with a high probability of being passed down from parents to their offspring.

Alterations that can be identified by a PGT-M :

  • Muscular Distrophy
  • Cystic Fibrosis
  • Sickle-cell anemia
  • Hemophilia 
  • Myotonic dystrophy
  • Thalassaemia
  • Tay sachs disease

We have learned that conducting these techniques increase the success of your IVF treatment by selecting the best embryos to be transferred.

At Ingenes, our staff is highly experienced and qualified to perform these complex techniques. We are the only institute in Mexico that conducts the entire procedures in-house, end to end - embryo biopsy, genetic analysis, genetic results interpretation – allowing us to provide the proper advice to our patients.