24 de October, 2023

Protect your baby before it is born

With the aim of giving security to couples who come to Ingenes to have a baby, our laboratories offer specialized techniques that will help us fulfill your desire.

There are several techniques that analyze the chromosomes of the embryo to diagnose genetic diseases, the best known is FISH, which allows the analysis of only 12 of the 23 pairs of chromosomes in each cell but is not very precise. Another technique that we use at Ingenes due to its high effectiveness is the Preimplantation Genetic Diagnosis (PGD) technique, which makes it possible to determine the complete chromosomal composition of an embryo in a single cell and its accuracy is between 96 and 98 percent.

In highly complex treatments, the complementary technique, Preimplantation Genetic Diagnosis (PGD), allows the embryos to be analyzed and determined if they have any chromosomal or genetic anomalies so that the most suitable ones are transferred to the uterus of the future mother.

Preimplantation Genetic Diagnosis (PGD) is performed on the third day of embryonic development when the embryo has approximately eight identical cells also called blastomeres. To achieve this procedure, it is necessary to perform an embryo biopsy, which consists of making a small opening on the surface of the embryo, through which a micropipette is introduced that aspirates from one to fifteen cells, all without affecting the development of the zygote.

The micromanipulation method will be the means by which the cells will be obtained, which will be analyzed through the Preimplantation Genetic Diagnosis (PGD) technique, to determine if an embryo contains the normal number of chromosomes that an individual should have.

The result of this analysis allows us to avoid congenital diseases, such as hemophilia, muscular dystrophy, and cystic fibrosis, among others. It is also possible to determine the sex of the embryo through this technique.

After identifying the embryos with the best shape and most likely to attach, we must wait 2 days to obtain the results of a genetic check. Then, when the embryos have grown a little more, we can transfer them. This helps us choose the embryos with the best quality and the best chance of success.

Preimplantation Genetic Diagnosis (PGD) is recommended for:

  • Couples are at risk of transmitting chromosomal alterations.
  • Couples with medical histories of recurrent abortion may occur due to an imbalance in chromosome number.
  • Couples with implantation failure after several cycles of In Vitro Fertilization (IVF).
  • Men with chromosomal alterations.
  • Women over 35 years of age.

The genetic diseases that can be determined through Preimplantation Genetic Diagnosis (PGD) are:

  • Down's Syndrome
  • Patau syndrome
  • Edward syndrome
  • Klinefelter syndrome
  • Turner syndrome
  • Triple X syndrome

among other.

If you are interested in learning more about Preimplantation Genetic Diagnosis (PGD), it is time for you to go to Ingenes where one of our specialists in Human Reproductive Biology will present the benefits you can obtain with this technique.

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