Implantation failure is diagnosed when a baby has not been achieved after at least three cycles of In Vitro fertilization (IVF) or the transfer of more than ten good quality embryos.
Currently, there are highly effective solutions for each of the causes of implantation failure, among which the transfer of embryos in the blastocyst phase (day 5 of embryonic development), preimplantation genetic diagnosis and assisted hatching (or assisted hatching).
Embryo implantation is a complex process that requires a healthy embryo and a receptive endometrium, as well as a close dialogue between the two.
In the field of assisted reproduction, implantation failure is diagnosed when a baby has not been achieved after at least three cycles of In Vitro fertilization (IVF) or the transfer of a total of ten good quality embryos.
The causes of implantation failure are multiple and both embryonic problems and problems with the uterine environment may be involved:
There are several tests that allow us to determine the causes of implantation failure:
It is important to note that a detailed evaluation of the cycles carried out so far (number of eggs obtained, fertilization rate, techniques used and embryonic development) is essential to establish an accurate prognosis.
Knowing the causes of implantation failure is essential when it comes to selecting a treatment that allows you to achieve a baby with the least wear and tear. Currently, there are highly effective solutions for each of these causes.
When implantation failure is associated with immunological problems, these can be easily treated with medications, while if it is due to problems with the uterine environment, treatment varies depending on the cause and can range from hormonal therapy to surgery in very specific cases. However, when implantation failure is due to embryonic problems, the main treatments include:
Until a few years ago, all embryos were transferred on the third day after fertilization because it was impossible to keep them alive in a laboratory, but today technology allows us to culture them for a longer time, which makes it easier to select the oldest embryos. quality and with greater power of implementation. (If you want to know more about prolonged embryo culture click here)
This technique allows only embryos free of chromosomal abnormalities (aneuploidies) to be transferred to the mother's uterus. This is related to implantation failure, recurrent pregnancy loss and the woman's age, since as the woman progresses, the risk of presenting chromosomal abnormalities in the baby increases.
This is why transferring only embryos free of these genetic alterations allows us to maximize the chances of implantation, pregnancy and having a baby at home regardless of the woman's age.
Before implantation in the uterus, the embryo must be freed from the membrane that surrounds it (zona pellucida) to come into direct contact with the cells of the endometrium. In some cases, implantation failure is due to the inability of the embryo to leave the zona pellucida and it is necessary to facilitate this process to increase the probability of implantation.
At Ingenes we have embryologists who are experts in micromanipulation techniques, which allows us to perform the laser-assisted hatching procedure quickly and accurately without causing any damage to the embryos.
"My experience with Ingenes was very calming all because of the staff, they were welcoming and made you feel at ease with everything."
Ingenes McAllen, TX.