MORE® In Vitro Fertilization Opens New Possibilities

MORE®, which stands for Magnetic Ovulatory Restoration, goes beyond traditional assisted reproduction methods, marking the beginning of a new era in fertility treatments.

It is specially designed for individuals facing challenges in egg quality due to:
Advanced age
Endometriosis
Polycystic Ovary Syndrome (PCOS)
Repeated failed IVF attempts

Understanding the Role of Age in Human Reproduction

Age is the main factor affecting fertility in women, as egg quality declines with aging, especially after 35 years, according to the World Health Organization. This fertility reduction is associated with a lower quantity and reduced quality of eggs. Additionally, the risk of miscarriage also increases with age, being more likely after 40.

According to the Society for Assisted Reproductive Technology, only 10% of patients between 41 and 42 achieve a viable embryo, so ovarian restoration is recommended before fertilization. This is where the innovative approach of MORE® comes in, incorporating advanced techniques to improve egg quality and embryo development, setting a precedent in the field of assisted reproduction.

Before MORE®, options were limited for these patients, often resorting to egg donation. MORE® offers an alternative for ovarian restoration, providing a better chance for eggs to divide correctly and result in a viable embryo.

Egg quality deteriorates with age, making fertilization and early embryo development difficult due to the lack of necessary components or energy in the cytoplasm. This can cause genetic abnormalities that may be transmitted to the embryo, leading to developmental problems or implantation failures. While age is the most important factor, endometriosis and Polycystic Ovary Syndrome (PCOS) also negatively impact embryo viability.

One in six women may have endometriosis. This condition occurs when menstrual blood flows towards the ovaries, affecting egg production and quality. This can form cysts called endometriomas, making the eggs dark and granular, reducing their fertilization and development capacity. In PCOS, insulin resistance and excess androgens prevent eggs from maturing properly, increasing genetic abnormalities and miscarriage rates.

MORE® offers new hope for these women, allowing the restoration of eggs even in women over 40, improving their chances of achieving a viable embryo.

What is IVF MORE®?

MORE® is our exclusive treatment that improves egg quality with advanced technology and techniques like micromanipulation and magnetic fields. We use a patented and proprietary recipe to revitalize them, helping them divide correctly and form viable embryos, offering new hopes in fertility.

How MORE® Works with In Vitro Fertilization: A Step-by-Step Guide

Egg Banking:

Our process starts with collecting the patient’s eggs. To increase the number of eggs collected, we apply hormonal stimulation. If we obtain more than six eggs and they are of good quality, a single treatment session will suffice. However, if the eggs are few or are dark and granular, we suggest a second stimulation session to ensure enough quality eggs before proceeding with our MORE® technique.

The goal is to freeze these eggs in less than six months. Even if a patient produces very few eggs, we can proceed with the MORE® technique, as we only need at least one egg to attempt the treatment.

Metabolic Diagnosis:

We have identified factors that allow us to detect the metabolic state of each egg and obtain a diagnosis. Some of these factors, such as Annexin V and other Krebs Cycle markers, are determinants for the correct metabolic development of the eggs. We will obtain a metabolic profile that tells us if the egg has enough metabolites to divide correctly and if it has enough energy to divide correctly.

Oocyte Restoration:

We enhance the egg with a recipe patented by Regenera®, which consists of an intracytoplasmic transfusion to poor-quality oocytes with growth factors and essential energy components to give the egg better chances of fertilizing and reducing the risk of producing an embryo with genetic abnormalities. This method uses advanced techniques such as biomolecular technology and digital PCR based on nanoplatelets to restore the egg.

In Vitro Fertilization (IVF):

We use the PICSI technique to fertilize the eggs. For this, it is essential to select the correct sperm. There is an alternative where sperm, through a microfluidics technique, travel through a channel. In this process, the best-quality sperm manage to exit from one end of the microfluidics to the other. The selected sperm bind to hyaluronan, an essential component of the zona pellucida of each egg. Simulating a natural process, we can filter and select the sperm that have the greatest ability to compete and advance through the microfluidic channel. By binding to hyaluronan, we have a greater probability that the sperm is of high quality, increasing the chances of obtaining a viable embryo with better potential.

Magnetic Field Culture:

We have found that by leaving the restored eggs in magnetic fields, there is an intracytoplasmic movement of solutes that allows better organization of the egg’s cytoskeleton. Once fertilized, we increase the potential of the magnetic fields to allow the egg to spend less energy and divide correctly. In other words, the magnetic fields have significantly increased the possibility of producing viable embryos.

Embryo Transfer to the Uterus:

Once we have viable embryos, we prepare the recipient woman’s endometrium using endometrial preparation techniques. In some cases, we use regenerative medicine techniques to increase the embryo’s implantation potential.

Who Can Benefit from MORE® IVF?

MORE® offers new hope for people who:

• Women over 40 who have seen their egg quality naturally decrease with age.

• Have gone through unsuccessful IVF cycles and feel they have exhausted their possibilities of conceiving with their eggs.

• Have conditions such as advanced endometriosis or Polycystic Ovary Syndrome (PCOS).

• Face fertility challenges due to genetic problems affecting embryo development.

• Patients who have had total embryo blockage.

• Patients who have undergone genetic embryo analysis and found all their embryos to be abnormal.

How Was MORE® Created?

MORE® was born from the dedication of researchers who discovered that egg quality deteriorates with age due to mitochondrial dysfunction. Then, our Regenera team identified key metabolites and factors linked to the egg's energetic and metabolic performance, leading to their proprietary recipe, IVF MORE®.

By using the patient’s mitochondria to revitalize the eggs and employing magnetic fields in embryonic culture, they facilitated proper cell division, significantly increasing the chances of obtaining viable embryos. This combination of metabolic diagnosis, egg revitalization, and magnetic fields has set a new precedent in assisted reproduction.

MORE® offers new hope to women with poor egg quality, including those with endometriosis and polycystic ovary syndrome, by reducing genetic errors and improving success rates in embryo development. This innovative solution provides an alternative for women who do not want to opt for egg donation, significantly improving the chances of successful pregnancies.

Overcoming Fertility Barriers Beyond Age

Although traditional IVF success rates decrease after 35, MORE® offers an innovative alternative. This treatment improves the chances of conceiving your eggs without resorting to egg donation. Instead of relying on younger donor eggs, MORE® helps overcome the challenges of age, endometriosis, and PCOS, providing new hope for achieving a successful pregnancy.

How Does MORE® Define Success in Fertility?

At MORE®, we understand how challenging it can be to achieve a viable embryo. In patients where ovarian restoration could not be achieved in a single attempt, it usually occurred because they had few eggs. But in up to 85% of cases, we have achieved viable embryos for transfer. In some cases, we had to repeat, but in most cases, we achieved a viable embryo.

Our treatment adds the necessary metabolites, growth factors, and energy components for the correct metabolism of the egg’s cytoplasm with a patented recipe, improving its quality. We adapt each treatment to the specific needs of your eggs, optimizing their chances of fertilization and embryo development.

At MORE®, we are here to accompany you every step of this exciting journey, offering you a real opportunity to fulfill your dream of becoming a mother.

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