Preimplantation Genetic Diagnosis

Realizing a dream means not losing sight of anything, not that you are looking for perfection, but the peace of mind that comes from knowing that everything will be fine without any anomalies.

What is Preimplantation Genetic Diagnosis?

Preimplantation Genetic Diagnosis (PGT) is the study of the DNA of embryos to select those that meet the characteristics of a normal one and discard those that have genetic alterations, before implantation.

This valuable procedure, which is carried out entirely within Ingenes, has made it the first and only Institute specialized in Assisted Reproduction in Mexico, which has this type of technology within its own facilities.

Why is it so important?

The importance of PGT lies in the analysis of the entire chromosomal complement in the embryos, the 24 types of chromosomes they contain, by means of microarray technology (a procedure that allows the identification and examination of both sex and genetic alterations to ensure that the embryos destined for transfer comply with the optimum characteristics and quality).

The cases in which patients could benefit from Preimplantational Genetic Diagnosis are

• Patients with a history of genetic abnormalities: Down or Turners Syndromes, Cystic Fibrosis, muscular dystrophy, haemophilia, etc.
• Patients aged 37 years and older.
• Family balancing (sex selection).
• Patients with a history of recurrent miscarriage.
• Patients who have had several good quality embryos. transferred and have not been able to become pregnant.

How is this done?

• It is performed at the stage of embryo division on day 3 of development or at the stage called blastocyst, which is the most advanced stage of the embryo in vitro culture, just before the embryo is transferred to the uterus of its future mother, and for this, it is necessary to carry out a cycle of Assisted Reproduction.

• The genetic material of each embryo is studied by means of an opening in the surface of the embryo (biopsy) and those with the genetic disease are discarded, selecting the healthy ones for transfer to the uterus.

• These biopsied cells are then placed in a tube with special solutions and transferred to the Genetics Laboratory within the Institute for analysis.

• Simultaneously, the embryos in culture are cryopreserved by means of a technique called vitrification, to keep them viable until they are thawed and transferred, once the result of their chromosomal analysis is known.

Age does not impede fulfilling your dream!

The application of Preimplantation Genetic Diagnosis and transfer of chromosomally normal embryos to our patients has allowed us to observe clear evidence of increased pregnancy rates in older women.

This is why this diagnostic method represents the opportunity to considerably increase a viable pregnancy, by selecting only genetically normal embryos to be transferred.