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What is IVF MORE®?

IVF MORE® (Magnetic Ovulatory Restoration) is a groundbreaking technique for restoring oocytes in women with poor egg quality, advanced maternal age, endometriosis, or polycystic ovary syndrome (PCOS).

The technique is specifically designed for individuals facing challenges related to egg quality due to:

  • Women over 35 with low ovarian quality
  • Endometriosis
  • Polycystic Ovary Syndrome (PCOS)
  • Repeated failed IVF attempts
  • Abnormal embryos (with chromosomal abnormalities, analyzed through PGT-A)

    Traditionally, when a woman’s oocytes showed issues in metabolism, structural organization, or cellular division, egg donation was considered the only viable option. IVF MORE® changes this paradigm by offering a patented scientific alternative to restore and optimize a patient's own oocytes, making pregnancy with her genetic material a real possibility.
Autologous Germline Mitochondria Energy Transfer : https://www.ncbi.nlm.nih.gov/pmc/articles/ PMC5545901/pdf/nihms880936.pdf Shoukhrat Mitalipov, Ph.D. / Center for Embryonic Cell and Gene Therapy : Meet Shoukhrat Mitalipov, Ph.D./ His pioneering work with mitochondria could help eliminate genetic disease: https://www.ohsu.edu/embryonic-cell-gene-therapy-center/meet-shoukhrat-mitalipov-phd 

How Does IVF MORE® Work?

IVF MORE® is an innovative technique that restores low-quality oocytes to increase the chances of pregnancy using the patient’s own eggs.

The process begins with ovarian stimulation to retrieve oocytes, which are then individually analyzed through a metabolic diagnosis that assesses their energy deficit. A cytoplasmic restoration is then performed using the patient’s own cells, replacing cellular energy and optimizing the oocyte’s fertilization capacity.

The best sperm are selected through advanced techniques, and in vitro fertilization is carried out. The resulting embryos are cultured in a magnetic field environment to support their development and ensure proper cell division.

Oocyte restoration helps reduce genetic abnormalities so that viable embryos can be transferred to the uterus under optimal conditions, increasing the chances of a successful pregnancy.

Benefits

Studies conducted with IVF MORE® have shown promising results:

  • Higher rate of viable embryos: In women with low oocyte quality, the number of viable embryos increased up to threefold compared to non-restored eggs, with 70% of restored embryos considered viable.
  • Reduced genetic risk: The rate of embryos with chromosomal abnormalities decreased from 82% to 26%—a percentage similar to that of young donor eggs.
  • Higher implantation and pregnancy rates: Patients over 40 who were previously unable to produce viable embryos are now able to achieve pregnancy using their own eggs.

Limitations

IVF MORE® is a revolutionary technique that restores the quality of oocytes, but there are cases in which its application is not possible.

The main limitation for undergoing IVF MORE® is the total absence of oocytes. This technique is designed to improve oocyte quality—without a mature egg to restore, the treatment cannot be performed.

In some cases, patients who have stopped menstruating may still produce at least one egg with ovarian stimulation. If a patient can still generate an egg, IVF MORE® becomes a viable option to increase her chances of achieving pregnancy using her own genetic material.

If no viable eggs are present, egg donation may be considered as an alternative to help the patient become a mother.

Edad avanza, el óvulo comete errores genéticos: Large cytoplasm predisposes oocytes to meiotic errors: http://www.cdb.riken.jp/en/news/2017/researches
/062910912.html#:~:text=The%20oocyte%27s%20large%
20cytoplasm%20is,segregation%20errors%20
observed%20during%20meiosis 

How Does IVF MORE® Work?

IVF MORE® is an innovative technique that restores low-quality oocytes to increase the chances of pregnancy using the patient’s own eggs.

Here we lay out the step by step process.
(Click on the numbers to learn about each part of the process)

1 →
2 →
3 →  
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1. Personalized Medical Consultation
Everything starts with a consultation to evaluate your case and determine the best treatment plan.
2. Ovarian Stimulation and Egg Retrieval
Your ovaries are stimulated to produce eggs. Once retrieved, the eggs are separated and vitrified along with the semen sample (if applicable) and granulosa cells.
3. Metabolic Diagnosis of the Egg
After thawing, the metabolic activity of the egg is analyzed to assess if it has the energy needed for proper cell division.
4. Oocyte Restoration
If needed, energy and mitochondrial factors are infused into the egg. In some cases, cytoplasm from a donor egg is used to support division—without altering the patient’s genetic material.
5. In Vitro Fertilization (ICSI)
The highest-quality sperm are selected through advanced techniques, and intracytoplasmic injection is performed.
6. Culture in Magnetic Fields
Embryos develop in a magnetic field environment that reduces cellular stress and supports accurate genetic division, minimizing chromosomal errors.
7. Embryo Transfer
In a deferred cycle, the viable embryo is transferred into a well-prepared endometrium. If needed, regenerative treatments such as Endogen® may be used to enhance implantation.
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Beneficios

Los estudios realizados con IVF MORE® han mostrado resultados prometedores:

  • Mayor tasa de embriones viables: En mujeres con baja calidad ovocitaria, el número de embriones viables aumentó hasta tres veces en comparación con óvulos no restaurados, con el 70% de embriones restaurados viables.
  • Reducción del riesgo genético: La tasa de embriones con alteraciones cromosómicas disminuyó del 82% al 26%, un porcentaje similar al de óvulos de donantes jóvenes. 
  • Mayor tasa de implantación y embarazo: Pacientes con más de 40 años que antes no lograban embriones viables ahora pueden embarazarse con sus propios óvulos.

Limitaciones

IVF MORE® es una técnica revolucionaria que permite restaurar la calidad de los óvulos, pero existen casos en los que su aplicación no es posible.

La principal limitación para someterse a IVF MORE® es la ausencia total de óvulos. Esta técnica está diseñada para mejorar la calidad ovocitaria: sin un óvulo maduro para restaurar, no se puede llevar a cabo el tratamiento.

En algunos casos, hay pacientes que han dejado de menstruar, pero que aún pueden producir al menos un óvulo al recibir estimulación ovárica. Si una paciente aún puede generar un óvulo, IVF MORE® es una opción viable para mejorar sus probabilidades de lograr un embarazo con su material genético.

En caso de que la paciente no presente ningún óvulo viable, se podrá recurrir a la donación de óvulos como una alternativa para que logren ser mamás.

Edad avanza, el óvulo comete errores genéticos: Large cytoplasm predisposes oocytes to meiotic errors: http://www.cdb.riken.jp/en/news/2017/researches
/062910912.html#:~:text=The%20oocyte%27s%20large%
20cytoplasm%20is,segregation%20errors%20
observed%20during%20meiosis 

The Problem: Egg Quality Deterioration

As women age, their eggs undergo metabolic and structural changes that impair their ability to generate viable embryos. These changes include:

  • Decreased energy production (ATP): Poor oocyte metabolism affects the cell division process.

  • Increased oxidative stress: The generation of reactive oxygen species (ROS) damages the egg's DNA and mitochondria.

  • Disruption of the cytoskeleton: The internal structures responsible for maintaining the egg’s shape and its ability to divide properly become disorganized.

  • Altered genetic signaling: Errors in the activation of key genes required for embryonic development.

These factors contribute to poor oocyte quality, failed IVF cycles, cycle cancellations, embryo arrest, and the formation of abnormal embryos (with chromosomal abnormalities), increasing the risk of pregnancy loss and implantation failure.

 Edad avanza, el óvulo comete errores genéticos: Large cytoplasm predisposes oocytes to meiotic errors: http://www.cdb.riken.jp/en/news/2017/researches/0629 _10912.html#:~:text=The%20oocyte%27s% 20large%20cytoplasm%20is,segregation%20errors %20observed%20during%20meiosis

The Solution: Egg Restoration with IVF MORE®

IVF MORE® addresses these issues through a multi-step approach:

1. Metabolic Oocyte Diagnosis
Before proceeding with restoration, the metabolic state of the eggs is assessed. After oocyte retrieval, samples of oocyte cytoplasm are analyzed to measure ATP, NADPH, and other key molecules. If an energy deficit is detected, restoration is performed using cytoplasm derived from the patient’s own cells.
2. Infusion of Growth Factors and Metabolic Regulators
Growth factors extracted from the patient’s cytoplasm are injected along with metabolic agents that optimize mitochondrial function. This helps the egg recover its energy-producing capacity and reduce oxidative stress.
3. Fertilization and Embryo Culture
Once restored, the eggs are fertilized with top-quality sperm selected via the PICSI technique and cultured under optimized conditions.

 Embryos derived from restored oocytes have been shown to have:

-A higher blastocyst formation rate (advanced-stage embryos)

-A lower incidence of chromosomal errors, reducing the need for egg donation

4. Embryo Culture in Magnetic Fields
One of the most innovative aspects of IVF MORE® is the use of magnetic fields to reorganize the internal structure of the oocyte.
Applied after fertilization, magnetic fields create the necessary energy for the oocyte’s cytoskeleton and ensure proper embryonic cell division. The cytoskeleton contains microfilaments that act as an internal “scaffold.” If these structures are disorganized, the egg may not divide properly, resulting in embryos with genetic abnormalities.


Magnetic field application during embryo culture allows for:

-Better mitochondrial distribution within the oocyte

-Activation and deactivation of calcium and magnesium channels essential for cell division

-Reduced energy expenditure in cytoskeleton reorganization, allowing the oocyte to focus its energy on proper development

If the metabolic diagnosis shows the oocytes have very low quality and restoration cannot be performed using the patient’s own cells, metabolic factors from a donor egg may be used to recover the oocytes. However, the patient’s full genetic material is preserved.

Magnetic Fields – Nature: https://www.nature.com/articles/srep37407 

IVF MORE® Origins

Innovation That Transforms Lives

At IVF MORE®, we combine cutting-edge science with regenerative medicine to offer new possibilities to those seeking to build a family. Our technique was developed in collaboration with Dr. Shoukhrat Mitalipov, pioneer in reproductive biology and college professor in Oregon, using the latest in molecular biology to restore low-quality oocytes. With over 19 babies born thanks to this technology—currently undergoing publication in high-impact scientific journals—we continue to move forward, delivering innovative and accessible solutions in assisted reproduction.

IVF MORE® is not just an assisted fertilization procedure—it is the result of years of research in reproductive biotechnology, molecular biology, and advanced micromanipulation. Its development represents an unprecedented breakthrough in oocyte restoration, giving women with poor oocyte quality or diminished ovarian reserve a renewed opportunity to conceive using their own eggs.

Shoukhrat Mitalipov, Ph.D. / Center for Embryonic Cell and Gene Therapy : Meet Shoukhrat Mitalipov, Ph.D./ His pioneering work with mitochondria could help eliminate genetic disease: https://www.ohsu.edu/embryonic-cell-gene-therapy-center/meet-shoukhrat-mitalipov-phd

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