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Celebrating World Fertility Day

Every year, June 4 is celebrated as World Fertility Day, a significant date to raise awareness about the importance of reproductive health and the challenges faced by people who want to start a family. This day is dedicated to educating and raising public awareness about the various causes of infertility, as well as promoting access to the treatments and support necessary to overcome it. At Ingenes, we join this global cause and are committed to providing advanced and personalized solutions to help people fulfill their dream of becoming parents. The Importance of Fertility in Global Health Fertility is a crucial component of a person’s overall health and well-being. The ability to conceive and carry a pregnancy to term is a fundamental part of life for many people and couples. However, infertility is a reality that affects millions of people around the world. According to the World Health Organization (WHO), it is estimated that between 10% and 15% of couples experience difficulties conceiving. World Fertility Day not only focuses on the medical aspects of infertility but also the emotional and psychological impact it can have on people. Infertility can lead to feelings of frustration, sadness, and stress, affecting quality of life and personal relationships. Causes and treatments of infertility Infertility can be caused by a variety of factors in both men and women. In women, common causes include ovulation problems, blockages in the fallopian tubes, endometriosis, and uterine problems. In men, causes may include problems with sperm production, blockages, and genetic factors. In many cases, infertility can be a combined problem where both members of the couple contribute to the difficulty conceiving. At Ingenes, we address infertility with a comprehensive and personalized approach. We offer a wide range of solutions ranging from assisted reproduction techniques such as intrauterine insemination (IUI) and in vitro fertilization (IVF), to more advanced procedures such as intracytoplasmic sperm injection (ICSI) and preimplantation genetic diagnosis (PGT). Additionally, we provide emotional and psychological support through counseling and support groups, understanding that emotional health is as important as physical health. Innovation and Hope at Ingenes Within the framework of World Fertility Day, it is important to highlight how innovation in fertility treatments has transformed the possibilities for many couples. At Ingenes, we pride ourselves on being at the forefront of these innovations. Our laboratories are equipped with the latest technology and our team of specialists is constantly trained in the most advanced techniques. For example, our IVF ABC program is designed to provide effective and accessible treatment for those who want to have another child. This program includes the essentials for fertilization and embryonic development and also offers additional options such as embryo cryopreservation and the use of advanced techniques such as ICSI. The future of fertility The celebration of World Fertility Day reminds us that there is still much to do to improve access to and quality of fertility treatments. It is essential to continue research and innovation to offer new solutions to the challenges that infertility presents. At Ingenes, we are committed to being part of this advancement, working tirelessly to offer our patients the best opportunities to build the family they want. World Fertility Day is an opportunity to reflect on the importance of reproductive health and the impact of infertility on the lives of many people. At Ingenes, we join this global cause and reaffirm our commitment to providing hope and solutions to those facing fertility challenges. Through innovative treatments, comprehensive support, and a patient-centered approach, we continue to work to make the dream of parenthood a reality for many people around the world.

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Fertility

Seminal infections

The seminal tract is the tube through which sperm travel from the testicles to the outside of the body. If there is an infectious process at any point along this route, the sperm are forced to pass through the infected area, damaging them and affecting their ability to fertilize the egg. Most seminal infections can be easily treated and cured with antibiotics. In case the quality of the sperm is insufficient, in vitro fertilization with intracytoplasmic sperm injection (IVF + ICSI) is the treatment of choice to achieve pregnancy. What are seminal infections? The seminal tract is the tube through which sperm travel from the testicles to the outside of the body. If there is an infectious process at any point along this path, the sperm are forced to pass through the infected area, damaging them and affecting their ability to fertilize the egg. Seminal infections affect fertility in several ways: The main symptoms of seminal infections Because seminal infections rarely present symptoms, it is common for them to remain unidentified for a long time and generate sequelae that can lead to infertility. In some cases, seminal infections can cause: If you have any of these symptoms, you should stop having sex and see a doctor immediately. Causes of seminal infections Seminal infections can be caused by the presence of harmful microorganisms in the prostate, seminal vesicles, vas deferens, epididymis, and testicles. These microorganisms are usually transmitted during unprotected sex. Any sexually active man can develop a seminal infection, however, the risk is proportional to the number of sexual partners he has or has had. How are seminal infections diagnosed? In addition to an analysis of your medical history and a genital examination that takes just a few minutes and is painless, a sperm culture or microbiological control of the semen is necessary. Current microbiological diagnostic techniques facilitate the detection of a large number of germs that affect semen quality and lead to male infertility, including parasites, bacteria, and fungi. The diagnosis must be made by an experienced specialist since there are numerous types of seminal infections and each requires a specific treatment. Similarly, it is advisable to perform a spectrogram or sinogram to rule out problems with sperm concentration, motility, and morphology. Treatments to achieve pregnancy when suffering from seminal infections In most cases, seminal infections can be easily treated and cured with antibiotics. Infected men should abstain from sexual relations until they and their sexual partners have been treated. Otherwise, they are at high risk of being reinfected and experiencing serious complications to their reproductive health. To ensure that the therapy has been effective, a follow-up check is recommended. In case of insufficient sperm quality, in vitro fertilization with intracytoplasmic sperm injection (IVF+ICSI) is the treatment of choice to achieve pregnancy thanks to the fact that it makes it possible to inject a single sperm directly into the cytoplasm of a mature egg using a microscopic needle. If the patient has an infection or the presence of leukocytes is determined in the sinogram, he or she must undergo appropriate treatment before starting an in vitro fertilization cycle. Similarly, it is advisable to perform a sperm DNA fragmentation test before starting any assisted reproduction treatment, since a high fragmentation rate could affect the success rates of these procedures.

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Assisted Reproduction

New Scientific Study on ENDOGEN: Advances in Fertility and IVF

A recent study published in the American Journal of Translational Research titled “Improving endometrial thickness and in vitro fertilization outcomes in patients with refractory endometrium using autologous mesenchymal stem cells” highlights an innovative technique to improve In Vitro Fertilization in complicated cases of infertility. This article was developed by researchers such as Dinorah Hernández-Melchor, Ginna Ortiz and Iván Madrazo, who are part of the Ingenes team of specialists, along with other collaborators. The use of stem cells from the stromal vascular fraction has shown positive results in restoring endometrial thickness in patients with refractory problems, offering new possibilities for the treatment of infertility in these cases. The article examines in depth how endogenous stem cells (ENDOGEN) can be used to improve egg quality and increase the chances of obtaining a viable embryo in patients with failures in previous In Vitro Fertilization (IVF) treatments. This breakthrough could make a significant difference in the management of infertility, especially in those cases where egg quality has been a challenge. The study highlights how stem cell-based therapies offer new hope, minimising the need for more invasive procedures such as egg donation. Preliminary results showed an increase in patients’ ability to produce healthy embryos, suggesting that ENDOGEN could become a standard tool in the future of assisted reproduction. You can read the full article here. At Ingenes, we are always on the lookout for the latest research to ensure we offer the best solutions to our patients. Advances in stem cell therapies, such as those presented in this study, bring us closer to providing more options to those who wish to fulfil their dream of having a baby.

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Fertility

The impact of hydrosalpinx on In Vitro Fertilization and strategies to improve success rates

Hydrosalpinx is a condition in which one or both fallopian tubes become filled with fluid, usually due to a previous infection or inflammation. This fluid, which can be toxic to embryos, poses a significant challenge for women seeking In Vitro Fertilization (IVF) treatments. When hydrosalpinx is present, the built-up fluid can leak into the uterus, decreasing IVF success rates and may even prevent embryo implantation. What is hydrosalpinx and how does it affect fertility? Hydrosalpinx develops when a fallopian tube becomes blocked and filled with serous fluid. This condition is often the result of previous infections, such as pelvic inflammatory disease, or surgery in the pelvic area. Although not all women with hydrosalpinx experience symptoms, some may notice pelvic pain, abdominal swelling, or abnormal vaginal discharge. The main problem with hydrosalpinx in the context of IVF is that the toxic fluid that builds up in the tubes can leak into the uterine cavity. Not only can this fluid prevent the embryo from implanting properly, but it can also directly damage the embryo, drastically reducing the chances of a successful pregnancy. For these reasons, it is crucial to address hydrosalpinx before starting an IVF cycle. Strategies to improve IVF success rates in the presence of hydrosalpinx When a woman is diagnosed with hydrosalpinx and is planning to undergo IVF treatment, there are several strategies to improve the chances of treatment success. Although solutions may vary from case to case, one of the most common recommendations is to perform a hysteroscopy to create a blockage in the tubal orifices. This procedure helps prevent toxic fluid from the fallopian tubes from reaching the uterus, thereby protecting the developing embryo. During hysteroscopy, the doctor inserts a small instrument through the cervix to access the inside of the uterus and fallopian tubes. It is used to block the tubal orifices, preventing fluid from passing into the uterus. This procedure is minimally invasive and can be very effective in improving implantation and pregnancy rates in women with hydrosalpinx. In more severe cases, where the hydrosalpinx is larger than 3 cm or where there is severe damage to the fallopian tube, laparoscopic surgery may be necessary to remove the affected tube. Laparoscopy is a minimally invasive surgery that allows the doctor to access the pelvic area through small incisions and with the aid of a camera. Although removing a fallopian tube may seem like a drastic measure, in many cases it is the best option to increase IVF success rates and avoid future fertility problems. Considerations before treatment Women with hydrosalpinx must receive a thorough diagnosis and proper evaluation before starting any fertility treatment. At Ingenes, the personalized approach and advanced technology allow specialists to offer recommendations based on each patient’s specific needs. Ingenes advises patients on the best options available to optimize the results of their treatments. In addition, women must maintain an open dialogue with their medical team about any concerns or symptoms they may experience. This ensures that any complications, such as hydrosalpinx, are managed in a timely and effective manner, thereby protecting the chances of success in IVF. Hydrosalpinx can have a significant impact on IVF success rates due to the presence of toxic substances in the fluid accumulated in the fallopian tubes. However, with proper diagnosis and correct management, it is possible to mitigate its effects and improve the chances of a successful pregnancy. Hysteroscopy to create a tubal blockage and laparoscopic surgery to remove the damaged tubes are viable options that can be considered depending on the severity of the case. As a leader in fertility treatments, Ingenes offers guidance and advanced solutions to help women overcome these challenges and get one step closer to their goal of starting a family. Patients must educate themselves and consult with specialists to make informed and personalized decisions.

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Fertility

The revolution of In Vitro Fertilization (IVF) and the role of the Fallopian Tubes

In vitro fertilization (IVF) has revolutionized the field of assisted reproduction since its first successful implementation in 1978. This scientific advancement has not only provided hope to millions of couples and single individuals worldwide. Still, it has also changed how we understand the Fallopian tubes’ role in the conception process. In this article, we will explore how IVF has made the Fallopian tubes non-essential for achieving pregnancy, and why this treatment offers higher success rates compared to other available methods. What is In Vitro Fertilization (IVF)? IVF is an assisted reproduction technique that involves fertilizing an egg with sperm outside the body, in a laboratory. Once the egg is fertilized and develops into an embryo, it is transferred to the woman’s uterus, where it can implant and result in pregnancy. The role of the Fallopian Tubes in natural conception In a natural pregnancy, the Fallopian tubes play an essential role. It is within these structures that the sperm meets the egg and fertilization occurs. Subsequently, the resulting embryo travels through the Fallopian tubes to the uterus, where it implants. However, various issues can affect the functioning of the Fallopian tubes, including blockages, infections, and damage from endometriosis or previous surgeries. These problems can prevent fertilization or the transport of the embryo, causing infertility. IVF eliminates the need for functional Fallopian tubes, as fertilization occurs in a laboratory. This advancement has been a lifesaver for many individuals with tubal issues, allowing them to conceive without the need for surgery to repair damaged tubes. Additionally, IVF offers a viable solution for a variety of other conditions that cause infertility, such as severe male factor infertility, irregular ovulation, and premature ovarian failure. IVF success rates One of the reasons why IVF is such a popular option is its high success rate compared to other fertility treatments. Statistics vary according to the patient’s age and medical condition, but generally, IVF offers higher pregnancy rates than other methods like intrauterine insemination (IUI). According to the American Society for Reproductive Medicine (ASRM), IVF success rates can be as high as 40% per cycle for women under 35 years old. At Ingenes, we use state-of-the-art technology and advanced techniques to maximize our patient’s chances of success. Advances in IVF IVF technology has advanced significantly since its inception. Some of the improvements include: The importance of emotional support The IVF journey can be emotionally challenging. At Ingenes, we provide comprehensive emotional support to our patients, understanding that mental health is crucial for treatment success. We offer individual and couples therapy, support groups, and stress management techniques to help our patients navigate their fertility journey with greater ease. IVF has transformed the way we approach infertility, making Fallopian tubes non-essential for conception and offering higher success rates compared to other fertility treatments. At Ingenes, we are committed to using the latest advances in assisted reproduction technology to help our patients achieve their dream of having a baby. With a holistic approach that includes emotional support, we ensure that each patient receives the best possible care. For more information about our in vitro fertilization services and emotional support, visit Ingenes.

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Fertility

Vaginal infections and their impact on female fertility

Within these conditions, vaginal infections such as Bacterial Vaginosis (BV) are one of the first causes of consultation for women of reproductive age. (Approximately 95% of patients who go to the gynecologist do so because of some type of infectious vaginal discharge). Vaginal infections affect women’s fertility since they belong to a large group of pathologies that generate varied clinical symptoms, ranging from uncomplicated processes to severe symptoms such as septic symptoms, which can compromise the lives of patients. When there is the presence of a vaginal infection, symptoms such as itching, irritation, and bad odor occur. However, it is very difficult to distinguish these infections from each other based only on the symptoms, and it is absolutely necessary to perform an examination and a microbiological study to establish the diagnosis. Speaking specifically about Bacterial Vaginosis (BV), it is first necessary to understand the function of the Normal Vaginal Flora, composed of microorganisms found in the vagina that, shortly after birth, change their constitution permanently throughout life. life in all women. Although efforts have been made to determine the characteristics of the microorganisms that compose it, there is still no absolute clarity of all the commensal agents of the Normal Vaginal Flora. However, the presence of BV is associated with a greater risk of infection in the upper genital tract and sexually transmitted infections such as HIV, affecting a third of sexually active women in the world. In addition to this, among the most common pelvic conditions we have Pelvic Inflammatory Disease (PID), which is a polymicrobial infectious pathology, caused by both sexually transmitted microorganisms and other bacteria that ascend from the vaginal tract to the pelvic structures. PID encompasses inflammatory and infectious processes of the upper genital tract and can be part of the following conditions: In pregnancy, BV is associated with spontaneous abortion, premature rupture of membranes, preterm delivery, chorioamnionitis, and postpartum endometritis. Fortunately, there are alternatives for those women who have had vaginal infections that have already impacted their fertility and who want to have a baby. The most effective technique is In Vitro Fertilization since it is the treatment that has the highest percentage of success and the best results. Ingenes Institute has several years of experience treating the largest number of and most complex fertility cases, so our team of specialists has all the experience to deal with infertility cases.

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Assisted Reproduction

Sperm bank for Assisted Reproduction treatments

At Ingenes we have a sperm bank designed to collect, select, and store semen samples to give couples with special cases of male infertility and single women who want to be mothers, the possibility of starting a family through Assisted Reproduction treatments. Our sperm bank has a wide variety of samples from people of different races and characteristics. In our bank, the selection and evaluation of sperm donors is carried out under the parameters established by the American Society for Reproductive Medicine (ASRM) and the World Health Organization, in addition to what is established by the competent Mexican authorities. Additionally, we provide men seeking to preserve their fertility the option of freezing their samples for future use in Assisted Reproduction treatments. Sperm donation Many children are conceived each year thanks to sperm donation, which gives couples, with special cases of male infertility and single women who want to be mothers, the possibility of starting a family through various Assisted Reproduction treatments. Sperm donation is a vital resource for: At Ingenes we have a sperm bank made up of samples from carefully evaluated and selected donors. These are mostly university students under 30 years of age who have decided to be donors for altruistic reasons and go to the bank selflessly. The selection and evaluation of donors is carried out under the parameters established by the American Society for Reproductive Medicine (ASRM) and the World Health Organization, in addition to what is established by the competent Mexican authorities. Likewise, the handling of samples is closely supervised by the National Transplant Center (CENATRA) and only a small percentage of men willing to be donors are accepted into our program. Potential sperm donors undergo extensive medical and psychological testing, as well as a detailed survey about their background, lifestyle, and family medical history. Likewise, it is verified that the semen sample freezes and thaws appropriately and is subjected to a chromosome analysis to verify that the donor’s karyotype is normal. Following the recommendations of the American Society for Reproductive Medicine (ASRM) and given that the AIDS virus can remain latent for up to six months, semen samples are frozen and kept in quarantine during this period to confirm its absence. Sperm donation is anonymous. Our patients can specify the physical characteristics of the donor they are looking for, however, they are advised that these are similar to their own, those of their partner, or their other children. In addition, the couple’s blood group is taken into account to assign the most suitable donor. At Ingenes we provide semen samples with concentration, mobility, and morphology conditions higher than those required by the World Health Organization. We have enough samples to meet the demands of our patients and a wide variety of donors with diverse physical characteristics. Likewise, we constantly renew our sperm donor base and limit the number of pregnancies achieved with each sample to avoid the risk of inbreeding between children of different patients with a common donor. Once a donor is chosen, semen samples can be processed by our experts for use in any Assisted Reproduction treatment, in which the chances of pregnancy will depend mainly on the age of the patient and the number and quality of their eggs. Our sperm bank staff is ready to work with you to determine the most appropriate Assisted Reproduction procedure for your circumstances, the type of donor you require, and the appropriate number of samples. It is important that patients considering sperm donation feel comfortable with the decision. Therefore, at Ingenes we have an emotional support unit to accompany them in the process, as well as qualified personnel willing to answer any questions they may have. Semen storage Semen banking is useful in a wide variety of situations: At the Ingenes bank, we do a complete analysis of your semen before storing it. We also perform a freezing test to determine the survival rate of your sperm and help you decide how many samples you need to freeze. Depending on the quality of the sperm and the Assisted Reproduction method that could be used later, it is recommended that you store one or two samples for each pregnancy you wish to achieve. Thanks to techniques such as In Vitro Fertilization with intracytoplasmic sperm injection (ICSI), in which a good quality sperm is enough to fertilize the egg, it is convenient that you freeze your semen even if it only has a few viable sperm. Semen can remain frozen indefinitely as long as freezing conditions remain constant. In addition, you can be sure that your samples will not be confused or mixed with those of other patients thanks to the fact that at Ingenes we have a rigorous system of labeling, identification, inventory, and storage of samples.

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que-es-la-miomatosis-uterina-y-como-afecta-tu-fertilidad
Fertility

What is uterine myomatosis and how does it affect fertility?

Uterine myomatosis is the appearance of myomas or fibroids inside the uterus. These are benign tumors classified by their location.  The myomas or fibroids inside a woman’s uterus are classified in the following way, according to their location:   Intramural: located in the uterus muscle wall and can affect fertility if they reach more than 4 centimeters.  Submucosal: formed in the surface of the uterine lining and can affect embryo implantation. Subserosal: located in the outer cover of the uterus and usually doesn’t affect fertility. Is it a common condition? It is the most common pelvic tumor. Approximately 20% of women suffer of uterine myomatosis during their reproductive age (from their first menstruation until menopause) and particularly women ovdf the age of 30.  Uterine myomas can be microscopic or slowly grow until filling the entire uterus. They have different shapes and sizes, and although they could be just one, most of the time are multiple.  How does uterine myomatosis affect fertility? These tumors are present in both fertile and infertile women. Nevertheless, 80% of the cases of infertility because of the uterine factor, is because of the appearance of uterine fibroids that affect the uterine cavity, like the case of intramural and submucosal.  The location of the uterine fibroids is very important because this determines whether they can potentially cause infertility, change sperm flow, or negatively affect the embryo implantation process.  Could this condition affect pregnancy?  Uterine myomas can cause compilations in the pregnancy process, such as:   High risk of miscarriage  Fetal growth retardation Premature delivery because of less space in the uterus Obstruction of the cervical canal  Obstruction of labor  Postpartum hemorrhage What are the symptoms?  Around 25% of uterine myomas are asymptomatic. But they can also manifest through:  Feeling of pressure in lower abs  Abnormally abundant menstrual bleeding  Longer than usual menstrual cycles Painful pelvic cramps Bleeding not related to menstruation  Pain or difficulty while peeing  Infertility Recurrent miscarriages It is important to point out that uterine myomatosis symptoms depend on the size, location and number of present fibroids.  What are the causes?  Although science hasn’t found the specific cause of the uterine myomas, it is known that appearance is related with genetic predisposition.  Also, the growth is associated with hormonal changes in the ovaries, in particular with progesterone and estrogen production.  Uterine fibroids appear during the reproductive stage of women, growing during pregnancy (when there is a high level of hormones), and disappear after menopause when the hormone levels are lower.  How can I get a diagnosis?  Reaching a specialist is the first step. The next one, probably, would be a vaginal ultrasound. Which is the most reliable study for uterine myomatosis diagnosis.  It offers nearly 95% of accuracy when done abdominally and 100% when done intravaginally.  The vaginal ultrasound must be interpreted by an expert. Can I become a mother despite being diagnosed with Uterine Myomatosis?  When it comes to achieving a healthy pregnancy,  treatment of uterine myomatosis depends on the age of the woman, and, above all, the size and location of the fibroids.  Subserosal myomas rarely affect fertility, but patients with submucosal or intramural fibroids larger than 2 inches, are recommended to consider treatments such as In Vitro Fertilization (IVF), especially if they are over the age of 35.  In Vitro Fertilization (IVF) is highly effective when uterine myomatosis does not affect the endometrial cavity.  Fibroids usually change sperm traffic and the embryo implantation process, but In Vitro Fertilization makes it possible for egg fertilization to take place in the laboratory.  Later, the embryo with the highest implantation potential is transferred into the uterus. How do I prepare for the process?  Very rarely do women have to go through a myomectomy before proceeding with the In Vitro Fertilization (IVF) treatment.  This is a surgery to take out the uterine fibroids, after which the pregnancy probability increases and there is an important decrease in the risk of miscarriage.  The new IVF cycle must be performed immediately after the uterine myomectomy because the probability of pregnancy decreases after the first year due to uterine fibroids’ recurrence.  If you would like to learn more about uterine myomatosis, visit our guide: What is Uterine Myomatosis?

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donacion-de-ovulos-tu-vientre-modifica-los-genes-de-tu-bebe
News

Egg donation: your womb changes your baby´s genes

A mother who carries a baby in her womb modifies her genes, even when the egg used is from another woman, which means that her child will be born with similar traits to her, according to research carried out by the Valencia Infertility Institute Foundation (IVI). Ovodonation, a chance for life Egg donation gives thousands of people the chance to experience pregnancy and have a baby through the process of In Vitro fertilization (IVF). In Vitro Fertilization (IVF), but taking this step during the process can be a difficult thing to go through. When hearing the word “embryo donation”, it is natural that many patients have all kinds of fears and doubts. ovodonationIt is natural that many patients have all kinds of fears and doubts, because the cell that will form their embryo belongs to another woman; but recent studies about the genetics of embryos show that they are modified during the gestation process. A finding that may go a long way to dispel many of the prejudices and misconceptions about cell donation. Their egg, your womb and their genetics What happens inside the womb is much more important than the egg itself, as a number of changes occur inside the egg that will influence the development of the embryo and even the growth of the person after birth. The development of a baby involves much more than an egg and sperm or their union, it involves its formation inside the womb for 9 months, during which different processes take place that directly influence its genetics, even modifying certain traits such as: IVF research found that there is a direct relationship between the developing embryo and the gestating mother, in which the baby’s genome is modified, as an exchangetakes place between the embryo and the endometrium, which is the inner tissue of the uterus. While the egg-donating mother will not contribute the entire genetic load of the baby, she will shape its genes, directly influencing its traits, expressions and even its ability to react to certain diseases. How does the genetic exchange between the embryo and your womb take place? The endometrial fluid contains vesicle-like sacs called exosomes, which in turn are loaded with RNA molecules from the mother, which come into direct contact with the nucleus of the embryo, where the embryo’s genes are located. This mixture is responsible for regulating the expression of certain specific genes, so that some traits emerge and others do not. This exchange occurs in the same way when a mother does not undergo a process of Assisted Reproduction with egg donation; so that her baby, the shapes and traits that he will later manifest, are also defined in the gestation process While in the womb, the embryo develops through the umbilical cord, receiving blood, food and oxygen that are directly dependent on its mother’s genetics, habits and lifestyle, transmitting a wealth of information that will undoubtedly influence how it will look, speak and smile. Egg donation: one small cell, one big chance The egg donation represents a unique opportunity for many women who yearn to become mothers by receiving a cell that will subsequently form and grow inside them, to which they will imprint their own genes, moulding them over the course of 9 months. Therefore, once your baby is born, he or she may display different physical traits similar to his or her mother, ranging from Chinese hair and honey-coloured eyes to a particular way of laughing. In this sense, an egg donation is a small help to be able to experience one of the most incredible stages of human nature: to gestate and give life to a baby that will have your blood and genes moulded by you, a person who will be 100% your child today and forever. Source: 1. F. Vilella, J. M. Moreno-Moya, N. Balaguer, A. Grasso, M. Herrero, S. Martínez, A. Marcilla , C. Simón. “Hsa-miR-30d, secreted by the human endometrium, is taken up by the pre-implantation embryo and might modify its transcriptome” (2015). 

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Fertility

Fertility problems? You’re not alone

The reality of fertility today It’s not something you talk about every day, but facing fertility challenges is more common than you imagine. It is estimated that 1 in 6 couples go through this situation. However, there is good news! We live in a time where science and medicine have advanced dramatically, offering real solutions to this problem. Ingenes: Where dreams come true Not all fertility clinics are the same. At Ingenes, we are proud to have a 92% success rate in treatments, which places us at the top in Latin America and exceeds the average of many renowned clinics in the United States. But what is our high success rate due to? In large part, it is thanks to our dedication, experience, and the support of important institutions. Ingenes has the recognition and support of both national and international organizations. Some of these are the National Council of Science and Technology (Conacyt), the prestigious Fertility Center of Illinois, and Cinvestav. Why choose Ingenes? Choosing a fertility clinic is an extremely important decision. It is essential to have expert professionals and cutting-edge technology. At Ingenes, we not only have both, but we also offer you human and personalized treatment, because we know that each story is unique. Your path to parenthood If you and your partner are experiencing fertility challenges, you are not alone. The Ingenes community is here to support you every step of the process, from diagnosis to the exciting moment of welcoming a new member into your family. Ready to start your journey to parenthood? Click here and discover how Ingenes can help you make your dream of becoming a parent a reality.

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Assisted Reproduction

Medication Application

Most fertility medications are administered subcutaneously. This means that they are applied with a very small needle that only penetrates the skin, so they are painless. Medications to stimulate egg production must be prescribed by a fertility specialist and their effects must be carefully monitored through transvaginal ultrasounds and blood tests every two to three days. If you are about to undergo an assisted reproduction treatment such as In Vitro Fertilization (IVF), you must apply medications to stimulate your egg production and thus maximize your chances of pregnancy so that you have a baby. It is normal to feel nervous before the first application. This is usually the first time that most women inject themselves and the fear of not doing it right adds to the emotions they face due to their struggle with infertility. How to apply the medications? The process of applying fertility medications consists of following simple steps: Medication Tips Normal effects of the medication. During this process, you will have to undergo transvaginal ultrasounds and blood tests every two or three days. These allow you to monitor the development of the follicles (sacs that contain the eggs) and monitor your reaction to the medications. The medications cause some effects that are considered normal, including mood changes, breast engorgement, and headaches in very rare cases. For their part, if these medications are applied without the supervision of a specialist who monitors the patient’s progress, they can cause ovarian hyperstimulation syndrome, which affects less than 1 percent of patients. Ovarian hyperstimulation syndrome manifests itself with symptoms such as fever, nausea, fluid retention, and abdominal distention (which usually appear after egg retrieval or follicular aspiration). You should be treated by a specialist to avoid complications. It is very important that you contact the fertility specialist if you present any of these symptoms, if you have doubts regarding the application of medications, or if you administer a higher dose than indicated. Other symptoms that may occur are irritation in the application area or infection, in which case it is also important that you contact your doctor. Most common medications Your diagnosis and treatment plan will determine the combination of injectable medications you will require in each IVF cycle. Some of the most used are: Remember that before administering any medication it is very important that you have a diagnosis from a specialist, since it is the one indicated to monitor the evolution of the medications and will be your guide during the process until you manage to have a baby at home.

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Assisted Reproduction

How is In Vitro Fertilization carried out?

In vitro fertilization, better known by its acronym IVF, is an advanced technique that has opened new doors for couples who want to become parents. Here we detail its process and relevance. What is IVF? IVF is a procedure where oocytes (eggs) and sperm join together outside the body. This technique is a direct result of progress in reproductive medicine. The Origin of the Term “In vitro” comes from Latin, meaning “in glass.” This is because fertilization occurs in glass containers, such as test tubes and Petri dishes. Why opt for IVF? Originally designed to address problems in the fallopian tubes, IVF has been shown to be effective in treating various causes of infertility. Preparation and Procedure The success of IVF depends on the health of the oocytes and sperm, as well as the ability of the uterus to sustain the pregnancy. Ovular donors go through a stimulation process to produce multiple follicles. Once mature, the oocytes are extracted with precision, using an ultrasound-guided needle. Only the best quality oocytes are selected for the fertilization process. After approximately 48 hours, the fertilized oocyte evolves into an embryo ready to be transferred to the patient.

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clomifeno-sirve-para-quedar-embarazada-vientre-mujer-embarazada-omifin
Fertility

Can Clomiphene help me get pregnant?

El clomifeno es un medicamento que promueve la ovulación, y puede incrementar las probabilidades de un embarazo si es administrado de forma adecuada por médicos especialistas. Te explicamos cómo aquí.

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Fertility

What are Aneuploidies: causes, and how to prevent them?

Human somatic cells are diploid, they normally have 23 pairs of chromosomes (46 chromosomes), in which all the genes that make up the genome are distributed. Sex cells (eggs and sperm) are haploid and only contain half as many chromosomes. What is an aneuploidy? A cell that contains a normal chromosome load is known as euploid and when it has an abnormal number of chromosomes due to gains or losses in one or more chromosomes, it is called aneuploid. When the abnormal number results in a number of chromosomes less than 46 it is known as monosomy, while when there is a gain of chromosomes it is known as trisomy (more than 46). What are the causes? Most chromosome duplication and deletion errors originate during gametogenesis, mainly in oogenesis (during meiosis I), while another considerable percentage of errors arise during the first mitosis after fertilization. Around 50% of all embryos produced through assisted reproduction techniques are aneuploid, the rate of aneuploidy increases as maternal age increases. From the age of 37, a higher percentage of aneuploid embryos is produced. The trisomies most frequently found in IVF embryos are 16, 19 and 21, while monosomy 22 and partial loss of the Y chromosome are the most common monosomies. All monosomies (except X chromosome monosomy or Turner syndrome) are incompatible with life; However, all trisomies can give rise to a baby with serious health problems. The type of involvement, phenotypic characteristics and life expectancy of the affected individual will depend on the type of trisomy. Trisomy 21, for example, a condition that gives rise to Down syndrome and one of the most frequent trisomies (1 case in 700 occurs), is characterized by a phenotype prone to congenital heart disease, mental retardation of varying degrees, and a long life expectancy. average of 50 years. Why does it impact fertility? Around 35% of all implantation failures that occur in assisted reproduction treatments are due to the transfer of aneuploid embryos. Additionally, in a study carried out at our Institute, it was determined that a mostly aneuploid embryonic cohort negatively affects the implantation result. Alternative ways to having a baby without this condition posing a barrier Recommending and carrying out Preimplantation Genetic Diagnosis (PGD Ingenes) for all embryos achieved through IVF to know their chromosomal profile will avoid the transfer of aneuploid embryos. This behavior will increase the chances of implantation and pregnancy. PGT ​​should be performed on all embryos during In Vitro Fertilization, especially if the woman’s age is over 37, or if the couple has a family history of aneuploidies. Sources Hassold, T., and Hunt, P. (2001). To err (meiotically) is human: the genesis of human aneuploidy. Nature reviews Genetics 2, 280-291. Ramia, M., Musharrafieh, U., Khaddage, W., and Sabri, A. (2014). Revisiting Down syndrome from the ENT perspective: review of literature and recommendations. European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies 271, 863-869. Rubio, C., Bellver, J., Rodrigo, L., Castillon, G., Guillen, A., Vidal, C., Giles, J., Ferrando, M., Cabanillas, S., Remohi, J., et al. (2017). In vitro fertilization with preimplantation genetic diagnosis for aneuploidies in advanced maternal age: a randomized, controlled study. Fertility and sterility 107, 1122-1129.

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Fertility

Pregnancy after 35, the challenges every woman needs to be aware of

Getting pregnant after 35? Not deciding early enough to want to have children could cause you to lose the power of choice. If you knew that in two years’ time your chances of becoming a mother would be considerably reduced, would you change the way you are planning the course of your life? “I am 40 years old and it would have changed my life if someone had told me about infertility 20 years ago. Planning your childbearing doesn’t just mean deciding not to have children when you don’t want them, it also means being able to have them when you do. Luciana Mantero, writer, journalist and mother after the age of 35. So begins the TEDx Talk of the writer and journalist Luciana Mantero, who at the age of 33 found out that she had an early menopause . Due to her condition, she had to seek help to start a family through Assisted Reproduction treatments. On the road to having her baby, she discovered the opportunity to help other couples going through the same situation. Time is fertility’s worst enemy “What if I told you that in two years you would lose the opportunity to have children? Would you change your life plans?” asks Luciana. “If all of you were of reproductive age, 2,000 of you would have trouble having a child in the future, without knowing it today.” The good news is that Luciana is merely highlighting a hypothetical situation. The bad news is that, because there is no precise date when the opportunity to become a parent is completely lost, many people do not realise this until it is too late. Pregnancy after 35: the biological clock versus current cultural trends A woman in her 30s has a 20% chance of becoming pregnant with each cycle of unprotected sex. At 40, this probability drops to 5%, with an increased risk of miscarriage and genetic alterations that could cause her baby to manifest conditions such as Down’s Syndrome, compromising her quality of life. In the modern era, men and women are increasingly having trouble getting pregnant and having a baby. Difficulty in having children is a silent epidemic for which almost no one is prepared. Latin America experiences fertility decline According to data from Economic Commission for Latin America and the Caribbean (ECLAC), Latin America presents an accelerated fertility decline and fertility problems associated with delayed childbearing, which contrast with high rates of teenage pregnancy. This is a global issue that has been widely studied in recent years, largely due to the ageing of the world’s population. The biological clock is on one side and cultural trends on the other. Getting pregnant at 35, 37, 39, 41, 43, 45, 47…. “When I was 29, the idea of having a child came into my head,” explains Luciana. “I wasn’t entirely sure it was the right time, but we started trying anyway. It didn’t take long for me to get pregnant. Three years after my first child, Lucas, was born, and having experienced the wonders of motherhood, we decided to try for a second child. I was 33 when I was diagnosed with early menopause”. For Luciana, the diagnosis of early menopause was unexpected. According to her testimony, she was told by seven different doctors that it was impossible to get pregnant with her own eggs . Her options were adoption or egg donation. According to these doctors, her ovarian reserve was simply “too old”. “For two years, my routine consisted of having a blood test every day, plus dozens of transvaginal ultrasounds to monitor my ovulation. I went to a clinic for a hysterosalpingogram. Luciana Mantero, writer, journalist and mother after the age of 35. After all the physical wear and tear, Luciana sought spiritual relief and took a breather before continuing on her way. “I come from an atheist family, but even so, I went to the Virgen del Cerro to pray for another son,” she continues. “After a period of great mourning, I accepted that there was another way to a happy ending with the right tools and support. We took the path of ovodonation”. Pregnancy after 35: experience and opportunity Luciana wrote a book detailing her story and that of nine other women. Along her journey, she met hundreds of people from her native Argentina, men and women who were going through the same things she was. Luciana says the stories keep coming back to her, just as her second son, Joaquin, came back to her. “Do you know how you were conceived? Do you know if your parents had fertility problems or underwent treatment? Assisted Reproduction opportunities for pregnancy after 35 years of age Thanks to scientific advances, there are now a wide variety of alternatives for having a successful pregnancy after the age of 35 and ending with a baby at home. If you are planning a pregnancy there is even the possibility of freezing your eggs. Ideally, this should be done before the age of 30. After 30, the quality and quantity of eggs gradually decreases as time goes by. Many of us would like to believe that we live outside statistics, but of course, statistics are there for a reason: In Mexico, 1 in 6 people experience infertility problems. “We all feel we are outside the statistics, but the reality is that we all fit into them,” concludes Luciana. “I don’t want it to be too late for you. Don’t let your dream go unfulfilled because you didn’t decide in time”.

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Fertility

A beginner’s Guide to IVF

dación In Vitro o Fertilización In Vitro (FIV) es, actualmente, el método más eficaz de reproducción asistida. Aquí, te brindamos una guía con todo lo que necesitas saber sobre la FIV.

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Fertility

Let’s talk In Vitro Fertilization: Embryo Transfer

In Vitro Fertilization (IVF) is a commonly used assisted reproductive technology that has brought joy to many families worldwide. If you’re considering IVF, it’s crucial to understand its significant steps, one of the most important being embryo transfer. Let’s delve deeper into this exciting and crucial stage. What is Embryo Transfer? Embryo transfer in IVF is the process where a fertilized egg (now called an embryo) is placed into a woman’s uterus with the hope of achieving pregnancy. It is performed by a specialist using a soft and thin catheter under ultrasound guidance. This process is typically painless and requires no anesthesia. The Journey to the Embryo Transfer Before embryo transfer, the steps taken are essential in creating a healthy embryo. It starts with ovarian stimulation, where you will take medications to stimulate the growth of multiple eggs. These eggs are then retrieved in a minor procedure. After the egg retrieval, the eggs are fertilized with sperm in a lab to create embryos. These embryos are cultured for a few days while their quality and development are closely monitored. The Big Day: The Embryo Transfer Embryo transfer is a significant step in the IVF process. It’s crucial to ensure that the conditions are optimal for the embryo to implant successfully in the uterus. During the procedure, the selected high-quality embryo is gently transferred through the cervix and into the uterus. This procedure is usually quick and painless. After the transfer, you’ll rest for a short while before you can go home. You should take it easy for the next few days, but you can return to most of your normal activities. The Two-Week Wait The period after the embryo transfer and before you can take a pregnancy test is often called the “two-week wait.” It can be a period of anxiety and anticipation. Remember to take care of yourself during this time, both physically and emotionally. Understanding the Journey Each IVF journey is unique, and not every cycle results in a pregnancy. If the first attempt is unsuccessful, don’t lose heart. Our team of fertility experts is committed to supporting you every step of the way and discussing the next steps if needed. Embryo transfer is a significant step in your IVF journey. Understanding what it involves can help you feel more prepared and less anxious. We’re here to guide you through every step of your journey towards parenthood. Remember, patience and perseverance are key in this process. Believe in yourself, and never lose hope.

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